What the studies found, in whom, and what they have not tested yet. No ingredient here has been trialled in people on the injection; every line says where the evidence comes from.
Whey isolate, leucine and D3 for muscle
Found: in 380 older adults with low muscle, a whey drink with added leucine and vitamin D improved muscle measures over 13 weeks (the PROVIDE trial, 2015). In older adults losing weight on purpose, the same trio preserved muscle mass in a placebo-controlled trial (American Journal of Clinical Nutrition, 2015).
Why here: lean mass is 20 to 30 percent of the weight lost on these injections. Not tested: in people on the injection; the first such trial, LEAN-PREP, has no results yet.
PROVIDE, JAMDA 2015 · Verreijen, AJCN 2015 · Body composition review, 2025
Creatine for muscle
Found: decades of trials in healthy adults show creatine monohydrate helps keep and build muscle with training. Honest note: it holds water in the first weeks, one to two kilos with a loading phase, less at 3 g a day without one.
Not tested: in people on the injection.
Loading vs no loading, 2025 preprint
Thiamine against the vomiting weeks
Found: 15 cases of Wernicke encephalopathy, a thiamine-deficiency brain injury, in people on semaglutide or tirzepatide (Clinical Nutrition, 2025), and six published semaglutide cases in a 2026 systematic review (Obesity). Guidance for people at risk uses 50 to 100 mg a day of oral thiamine.
Why here: weeks of nausea and vomiting plus very little food is exactly the risk pattern. 30 mg sits inside every country's limit. Not tested: no prevention trial in people on the injection.
Clinical Nutrition 2025 · Obesity 2026 review · Prevention guidance
Calcium, K2 and D3 for bone
Found: in a 52-week randomised trial of 64 adults, semaglutide lowered hip bone density by 2.6 percent and spine by 2.1 percent against placebo, with more bone breakdown and no extra bone building (eClinicalMedicine, 2024). A 2025 cohort of 66,000 tirzepatide users found 44 percent more new osteoporosis or fractures than on other GLP-1 drugs. K2 improved spine density in a 2025 meta-analysis of 16 trials in postmenopausal women.
Not tested: no trial has given calcium, D3 or K2 to people on the injection. The support is bone guidance after bariatric surgery and the K2 trials above.
Semaglutide bone trial, 2024 · Tirzepatide cohort, 2025 · K2 meta-analysis, 2025
PHGG fiber for a slowed gut
Found: partially hydrolysed guar gum is a low-viscosity fiber used in constipation studies, and it does not thicken in the stomach the way psyllium or glucomannan do. Why here: the injection already slows the stomach; thick fibers slow it more, and nobody has tested that combination. Not tested: in people on the injection.
Joint nutrition advisory, 2025
Green kiwifruit for constipation
Found: two green kiwifruit a day improved constipation and abdominal comfort in a 184-person international crossover trial (American Journal of Gastroenterology, 2023). A kiwifruit extract at 575 mg twice a day improved complete bowel movements and stool consistency in 186 people with constipation-type IBS (2025). A low 1 g freeze-dried powder did nothing, so the form and dose matter and the maker sets them with us.
Not tested: in people on the injection.
AJG 2023 · JGH Open 2025
Magnesium citrate at night
Found: magnesium citrate draws water into the gut, which is why it is the form usually picked when the gut is slow; loose stools are the limit, which is why the pack starts at half. Not tested: at exactly 150 mg in a dedicated trial, and not in people on the injection.
Magnesium supplementation review
Ginger against nausea
Found: an overview of 15 meta-analyses found ginger reduces nausea after chemotherapy, after surgery and in pregnancy; trials used 500 to 1,500 mg a day. Honest note: it reduces nausea more than vomiting, and it can interact with blood thinners such as warfarin. Not tested: in people on the injection.
Overview of reviews, 2023 · Ginger interactions
Sodium, potassium, magnesium in the morning glass
Found: people on the injection eat 500 to 650 fewer calories a day and drink less, and nausea, vomiting and diarrhea cost fluid and salt. Honest note: no controlled trial has tested electrolytes alone against headache or tiredness in any group, so we do not claim that. We put back what a normal day of food and drink carries, at gentle amounts within each country's limits.
Nature Medicine, 2025 · US prescribing information
D3, B6, B12, folate, C and zinc
Found: the 2025 joint advisory from four US medical societies lists preventing micronutrient deficiency as a priority for people on the injection, based on how little they eat. Honest note: B6 stays at a daily-value level. Its nausea evidence exists only in pregnancy at far higher doses, and Europe cut its safety limit to 12 mg in 2023, so we do not use it for nausea.
Joint advisory, 2025 · EFSA B6 opinion, 2023
Replen is food. None of this treats, cures or prevents a disease, and none of it has been trialled in people on the injection. The studies are linked so you can read them yourself.